Tumor Suppressor Genes
Tumor suppressor genes are normal genes that inhibit cell division and prevent uncontrolled cell growth. When these genes are mutated or deleted, cells can grow uncontrollably, leading to cancer.
Key points about tumor suppressor genes:
- Tumor suppressor genes regulate cell cycle checkpoints and apoptosis (programmed cell death).
- Loss of function mutations in tumor suppressor genes can contribute to cancer development.
- Examples include p53 (often called the "guardian of the genome") and RB1 (Retinoblastoma gene).
Disclaimer
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